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Image Search Results
Journal: Journal of Diabetes Science and Technology
Article Title: Near-Infrared Optical Nanosensors for Continuous Detection of Glucose
doi: 10.1177/1932296819886928
Figure Lengend Snippet: A dual component system for fluorescence-based glucose sensing. A boronic-acid modified viologen molecule associates with an anionic fluorophore to quench fluorescence. Upon binding of glucose with the boronic acid moieties, the viologen is neutralized to increase the effective fluorescence of a near-infrared dye.
Article Snippet:
Techniques: Fluorescence, Modification, Binding Assay
Journal: Journal of Diabetes Science and Technology
Article Title: Near-Infrared Optical Nanosensors for Continuous Detection of Glucose
doi: 10.1177/1932296819886928
Figure Lengend Snippet: Two-component glucose sensing chemistry is concentration dependent. (a) 2-Hydroxyethyl methacrylate hydrogels containing IRDye680 and viologen boronic acid at a fixed 10:1 ratio in a range of concentrations were challenged with the addition of glucose (i, 1:0.1; ii, 5:0.5; iii, 10:1; and iv, 15:1.5). (b) Intensity ratios of glucose sensitive hydrogels reveal that higher total concentrations of IRDye680 and viologen boronic acid improve glucose sensitivity.
Article Snippet:
Techniques: Concentration Assay
Journal: Journal of Diabetes Science and Technology
Article Title: Near-Infrared Optical Nanosensors for Continuous Detection of Glucose
doi: 10.1177/1932296819886928
Figure Lengend Snippet: Detection of viologen boronic acid quencher on glucose nanosensors. (a) Treatment of viologen boronic acid with NaOH results in the appearance of an absorbance peak at 400 nm. (b) Absorbance of viologen boronic acid at all concentrations plateau after treatment with 10 mM NaOH. (c) Standard curves of viologen boronic acid are indistinguishable after treatment with at least 10 mM NaOH.
Article Snippet:
Techniques:
Journal: Journal of Diabetes Science and Technology
Article Title: Near-Infrared Optical Nanosensors for Continuous Detection of Glucose
doi: 10.1177/1932296819886928
Figure Lengend Snippet: Optimization of glucose nanosensor fabrication. (a) Synthesis scheme of glucose nanosensors with IRDye680 and viologen boronic acid quencher. (b) Comparison of silica nanoparticles reacted with IRDye680/viologen boronic acid (left) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride/N-hydroxysulfosuccinimide activated IRDye680/viologen boronic acid (right). (c) Glucose modulation of glucose nanosensors containing a range of IRDye680:viologen boronic acid ratios show that higher ratios provide better modulation. (d) Table of intensity ratios for particles treated with glucose and particles treated with control (saline) indicate that higher IRDye680:viologen boronic acid ratios have better modulation within physiological ranges (I200/I50) and limited drift in fluorescence upon addition of saline.
Article Snippet:
Techniques: Fluorescence